Publications

This section contains all publications where CORVOS has been acknowledged therein.
Note that the first PhD student in the CORVOS programme started in spring 2020.
Relevant publications antedating CORVOS are listed under Faculty members.

PUBLICATIONS
2025
Magda M, Boschloo W, Bettoni S, Fairley D, Russo TA, Giske CG, Tellapragada C, Rooijakkers SHM, Riesbeck K, Blom AM.
 
cinetobacter baumannii Clinical Isolates Resist Complement-Mediated Lysis by Inhibiting the Complement Cascade and Improperly Depositing MAC.
 
Roquigny J, Meuleman MS, El Sissy C, Cailliez M, Servais A, Roussey G, Baudouin V, Decramer S, Nobili F, Wynckel A, Sellier Leclerc AL, Lapeyraque AL, Martins PV, Meri S, Dragon-Durey MA, Chauvet S, Frémeaux-Bacchi V.
 
Functional Characterization of Anti-C3bBb Autoantibodies and C3 Glomerulopathy Phenotype.
  
PUBLICATIONS
2024
Götz MP, Duque Villegas MA, Fageräng B, Kerfin A, Skjoedt MO, Garred P, Rosbjerg A.
 
Transient Binding Dynamics of Complement System Pattern Recognition Molecules on Pathogens.
 
Revel M, Rezola Artero M, Hamidi H, Grunenwald A, Blasco L, Vano YA, Marie Oudard S, Sanchez-Salas R, Macek P, Rodriguez Sanchez L, Cathelineau X, Vedié B, Sautes-Fridman C, Herman Fridman W, Roumenina LT, Dragon-Durey MA.
 
Humoral complementomics - exploration of noninvasive complement biomarkers as predictors of renal cancer progression.
  
Sutta A, Leemans NN, Ploug M, Rosbjerg A, Del Agua Villa C, Pérez-Alós L, Cyranka L, Vincek AS, de Garay T, Rivera K, Bayarri-Olmos R.
 
CL-11 circulates in serum as functionally distinct isoforms.
 
Fageräng B, Lau C, Mc Adam KE, Schjalm C, Christiansen D, Garred P, Nilsson PH, Mollnes TE.
 
A novel selective leukocyte depletion human whole blood model reveals the specific roles of monocytes and granulocytes in the cytokine response to Escherichia coli.
  
Fageräng B, Götz MP, Cyranka L, Lau C, Nilsson PH, Mollnes TE, Garred P.
 
The Inflammatory Response Induced by Aspergillus fumigatus Conidia Is Dependent on Complement Activation: Insight from a Whole Blood Model.
 
Krzyżewska-Dudek E, Dulipati V, Kapczyńska K, Noszka M, Chen C, Kotimaa J, Książczyk M, Dudek B, Bugla-Płoskońska G, Pawlik K, Meri S, Rybka J.
 
Lipopolysaccharide with long O-antigen is crucial for Salmonella Enteritidis to evade complement activity and to facilitate bacterial survival in vivo in the Galleria mellonella infection model.
  
Masson FM, Káradóttir S, van der Lans SPA, Doorduijn DJ, de Haas CJC, Rooijakkers SHM, Bardoel BW.
 
Klebsiella LPS O1-antigen prevents complement-mediated killing by inhibiting C9 polymerization.
 
Scavello F, Brunetta E, Mapelli SN, Nappi E, García Martín ID, Sironi M, Leone R, Solano S, Angelotti G, Supino D, Carnevale S, Zhong H, Magrini E, Stravalaci M, Protti A, Santini A, Costantini E, Savevski V, Voza A, Bottazzi B, Bartoletti M, Cecconi M, Mantovani A, Morelli P, Tordato F, Garlanda C.
 
The long Pentraxin PTX3 serves as an early predictive biomarker of co-infections in COVID-19.
  
Ljungquist O, Magda M, Giske CG, Tellapragada C, Nazarchuk O, Dmytriiev D, Thofte O, Öhnström V, Matuschek E, Blom AM, Riesbeck K.
 
Pandrug-resistant Klebsiella pneumoniae isolated from Ukrainian war victims are hypervirulent.
 
Roquigny J, Meuleman MS, El Sissy C, Martins PV, Meri S, Duval A, Lequintrec M, Fakhouri F, Chauvet S, Frémeaux-Bacchi V.
 
Acquired and genetic drivers of C3 and C5 convertase dysregulation in C3 glomerulopathy and immunoglobulin-associated MPGN.
  
Bettoni S, Dziedzic M, Bierschenk D, Chrobak M, Magda M, Laabei M, King BC, Riesbeck K, Blom AM.
 
C4b-Binding Protein and Factor H Attenuate NLRP3 Inflammasome-Mediated Signalling Response during Group A Streptococci Infection in Human Cells.
 
Fageräng B, Cyranka L, Schjalm C, McAdam KE, Larsen CS, Heinzelbecker J, Gedde-Dahl T, Würzner R, Espevik T, Tjønnfjord GE, Garred P, Barratt-Due A, Tvedt THA, Mollnes TE.
 
The function of the complement system remains fully intact throughout the course of allogeneic stem cell transplantation.
  
Massri M, Toonen EJM, Sarg B, Kremser L, Grasse M, Fleischer V, Torres-Quesada O, Hengst L, Skjoedt MO, Bayarri-Olmos R, Rosbjerg A, Garred P, Orth-Höller D, Prohászka Z, Würzner R.
 
Complement C7 and clusterin form a complex in circulation.
 
Avraham M, Sinkovits G, Hurler L, Prohászka Z, Fishelson Z.
 
Circulating mortalin in blood and activation of the alternative complement pathway as risk indicators in COVID-19 infection.
  
Hurler L, Mescia F, Bergamaschi L; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration; Kajdácsi E, Sinkovits G, Cervenak L, Prohászka Z, Lyons PA, Toonen EJM.
 
sMR and PTX3 levels associate with COVID-19 outcome and survival but not with Long COVID.
 
PUBLICATIONS
2023
Hurler L, Szilágyi Á, Mescia F, Bergamaschi L, Mező B, Sinkovits G, Réti M, Müller V, Iványi Z, Gál J, Gopcsa L, Reményi P, Szathmáry B, Lakatos B, Szlávik J, Bobek I, Prohászka ZZ, Förhécz Z, Csuka D, Kajdácsi E, Cervenak L, Kiszel P, Masszi T, Vályi-Nagy I, Würzner R; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration; Lyons PA, Toonen EJM, Prohászka Z.
 
Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups.
 
Larsen ML, Troldborg A, Toonen EJM, Hurler L, Prohaszka Z, Cervenak L, Hansen AG, Thiel S.
 
Differentiating Between Activation via the Lectin or the Classical Complement Pathway in Patients with Systemic Lupus Erythematosus.
  
Janet-Maitre M, Pont S, Masson FM, Sleiman S, Trouillon J, Robert-Genthon M, Gallet B, Dumestre-Perard C, Elsen S, Moriscot C, Bardoel BW, Rooijakkers SHM, Cretin F, Attrée I.
 
Genome-wide screen in human plasma identifies multifaceted complement evasion of Pseudomonas aeruginosa.
 
van der Lans SPA, Janet-Maitre M, Masson FM, Walker KA, Doorduijn DJ, Janssen AB, van Schaik W, Attrée I, Rooijakkers SHM, Bardoel BW.
 
Colistin resistance mutations in phoQ can sensitize Klebsiella pneumoniae to IgM-mediated complement killing.
  
Kellnerová S, Huber S, Massri M, Fleischer V, Losso K, Sarg B, Kremser L, Talasz H, He X, Varrone E, Brigotti M, Ardissino G, Orth-Höller D, Würzner R.
 
Enzymatic Cleavage of Stx2a in the Gut and Identification of Pancreatic Elastase and Trypsin as Possible Main Cleavers.
 
Cyranka L, Mariegaard I, Skjødt MO, Bayarri-Olmos R, Mollnes TE, Garred P, Rosbjerg A.
 
Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody.
  
Ma YJ, Parente R, Zhong H, Sun Y, Garlanda C, Doni A.
 
Complement-pentraxins synergy: Navigating the immune battlefield and beyond.
 
González-Del-Barrio L, Pérez-Alós L, Cyranka L, Rosbjerg A, Nagy S, Prohászka Z, Garred P, Bayarri-Olmos R.
 
MAP-2:CD55 chimeric construct effectively modulates complement activation.
  
Götz MP, Skjoedt MO, Bayarri-Olmos R, Hansen CB, Pérez-Alós L, Jarlhelt I, Benfield T, Rosbjerg A, Garred P.
 
Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19.
 
PUBLICATIONS
2022
Medeiros PMC, Schjalm C, Christiansen D, Sokolova M, Pischke SE, Würzner R, Mollnes TE, Barratt-Due A.
 
Vitamin C, Hydrocortisone, and the Combination Thereof Significantly Inhibited Two of Nine Inflammatory Markers Induced by Escherichia Coli But Not by Staphylococcus Aureus - When Incubated in Human Whole Blood.
 
Magda M, Bettoni S, Laabei M, Fairley D, Russo TA, Riesbeck K, Blom AM.
 
Clinical Isolates of Acinetobacter spp. Are Highly Serum Resistant Despite Efficient Recognition by the Complement System.
  
Sinkovits G, Réti M, Müller V, Iványi Z, Gál J, Gopcsa L, Reményi P, Szathmáry B, Lakatos B, Szlávik J, Bobek I, Prohászka ZZ, Förhécz Z, Mező B, Csuka D, Hurler L, Kajdácsi E, Cervenak L, Kiszel P, Masszi T, Vályi-Nagy I, Prohászka Z.
 
Associations between the von Willebrand Factor-ADAMTS13 Axis, Complement Activation, and COVID-19 Severity and Mortality.
 
Henry BM, Sinkovits G, Szergyuk I, de Oliveira MHS, Lippi G, Benoit JL, Favaloro EJ, Pode-Shakked N, Benoit SW, Cooper DS, Müller V, Iványi Z, Gál J, Réti M, Gopcsa L, Reményi P, Szathmáry B, Lakatos B, Szlávik J, Bobek I, Prohászka ZZ, Förhécz Z, Csuka D, Hurler L, Kajdácsi E, Cervenak L, Mező B, Kiszel P, Masszi T, Vályi-Nagy I, Prohászka Z.
 
Complement Levels at Admission Reflecting Progression to Severe Acute Kidney Injury (AKI) in Coronavirus Disease 2019 (COVID-19): A Multicenter Prospective Cohort Study.
  
Bertacchi G, Posch W, Wilflingseder D.
 
HIV-1 Trans Infection via TNTs Is Impeded by Targeting C5aR. Biomolecules.
 
Massri M, Foco L, Würzner R.
 
Comprehensive Update and Revision of Nomenclature on Complement C6 and C7 Variants.
  
Khattab A, Rezola M, Barroso M, Kyrklund M, Pihlajamaa T, Freitag TL, van Gemert GJ, Bousema T, Permi P, Turunen O, Sauerwein R, Luty AJF, Meri S.
 
Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the Plasmodium falciparum parasite.
 
de Boer E, Sokolova M, Quach HQ, McAdam KE, Götz MP, Chaban V, Vaage J, Fageräng B, Woodruff TM, Garred P, Nilsson PH, Mollnes TE, Pischke SE.
 
Synthetic Oligodeoxynucleotide CpG Motifs Activate Human Complement through Their Backbone Structure and Induce Complement-Dependent Cytokine Release.
  
Sinkovits G, Schnur J, Hurler L, Kiszel P, Prohászka ZZ, Sík P, Kajdácsi E, Cervenak L, Maráczi V, Dávid M, Zsigmond B, Rimanóczy É, Bereczki C, Willems L, Toonen EJM, Prohászka Z.
 
Evidence, detailed characterization and clinical context of complement activation in acute multisystem inflammatory syndrome in children.
 
Hurler L, Toonen EJM, Kajdácsi E, van Bree B, Brandwijk RJMGE, de Bruin W, Lyons PA, Bergamaschi L; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration; Sinkovits G, Cervenak L, Würzner R, Prohászka Z
 
Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs
  
PUBLICATIONS
2021
Sinkovits G, Mező B, Réti M, Müller V, Iványi Z, Gál J, Gopcsa L, Reményi P, Szathmáry B, Lakatos B, Szlávik J, Bobek I, Prohászka ZZ, Förhécz Z, Csuka D, Hurler L, Kajdácsi E, Cervenak L, Kiszel P, Masszi T, Vályi-Nagy I, Prohászka Z.
 
Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection.
 
Posch W, Vosper J, Noureen A, Zaderer V, Witting C, Bertacchi G, Gstir R, Filipek PA, Bonn GK, Huber LA, Bellmann-Weiler R, Lass-Flörl C, Wilflingseder D.
 
C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2-infected primary human airway epithelia.
  
Huber S, Massri M, Grasse M, Fleischer V, Kellnerová S, Harpf V, Knabl L, Knabl L Sr, Heiner T, Kummann M, Neurauter M, Rambach G, Speth C, Würzner R.
 
Systemic Inflammation and Complement Activation Parameters Predict Clinical Outcome of Severe SARS-CoV-2 Infections.
 
publications

Publications 2025:
Magda M, Boschloo W, Bettoni S, Fairley D, Russo TA, Giske CG, Tellapragada C, Rooijakkers SHM, Riesbeck K, Blom AM. : cinetobacter baumannii Clinical Isolates Resist Complement-Mediated Lysis by Inhibiting the Complement Cascade and Improperly Depositing MAC. J Innate Immun. 2025;17(1):112-125. doi: 10.1159/000543664. Epub 2025 Jan 22.
Roquigny J, Meuleman MS, El Sissy C, Cailliez M, Servais A, Roussey G, Baudouin V, Decramer S, Nobili F, Wynckel A, Sellier Leclerc AL, Lapeyraque AL, Martins PV, Meri S, Dragon-Durey MA, Chauvet S, Frémeaux-Bacchi V. : Functional Characterization of Anti-C3bBb Autoantibodies and C3 Glomerulopathy Phenotype. J Am Soc Nephrol. 2025 Feb 1;36(2):264-273. doi: 10.1681/ASN.0000000000000499. Epub 2024 Sep 26.

Publications 2024:
Götz MP, Duque Villegas MA, Fageräng B, Kerfin A, Skjoedt MO, Garred P, Rosbjerg A. : Transient Binding Dynamics of Complement System Pattern Recognition Molecules on Pathogens. J Immunol. 2024 May 1;212(9):1493-1503. doi: 10.4049/jimmunol.2300768.
Revel M, Rezola Artero M, Hamidi H, Grunenwald A, Blasco L, Vano YA, Marie Oudard S, Sanchez-Salas R, Macek P, Rodriguez Sanchez L, Cathelineau X, Vedié B, Sautes-Fridman C, Herman Fridman W, Roumenina LT, Dragon-Durey MA.: Humoral complementomics - exploration of noninvasive complement biomarkers as predictors of renal cancer progression. Oncoimmunology. 2024 Mar 13;13(1):2328433. doi: 10.1080/2162402X.2024.2328433.
Sutta A, Leemans NN, Ploug M, Rosbjerg A, Del Agua Villa C, Pérez-Alós L, Cyranka L, Vincek AS, de Garay T, Rivera K, Bayarri-Olmos R.: CL-11 circulates in serum as functionally distinct isoforms. FASEB J. 2024 Mar 15;38(5):e23543. doi: 10.1096/fj.202301765R.
Fageräng B, Lau C, Mc Adam KE, Schjalm C, Christiansen D, Garred P, Nilsson PH, Mollnes TE.: A novel selective leukocyte depletion human whole blood model reveals the specific roles of monocytes and granulocytes in the cytokine response to Escherichia coli. J Leukoc Biol. 2024 Mar 29;115(4):647-663. doi: 10.1093/jleuko/qiad151. Erratum in: J Leukoc Biol. 2024 May 29;115(6):1190. doi: 10.1093/jleuko/qiae088.
Fageräng B, Götz MP, Cyranka L, Lau C, Nilsson PH, Mollnes TE, Garred P.: The Inflammatory Response Induced by Aspergillus fumigatus Conidia Is Dependent on Complement Activation: Insight from a Whole Blood Model. J Innate Immun. 2024;16(1):324-336. doi: 10.1159/000539368. Epub 2024 May 20.
Krzyżewska-Dudek E, Dulipati V, Kapczyńska K, Noszka M, Chen C, Kotimaa J, Książczyk M, Dudek B, Bugla-Płoskońska G, Pawlik K, Meri S, Rybka J.: Lipopolysaccharide with long O-antigen is crucial for Salmonella Enteritidis to evade complement activity and to facilitate bacterial survival in vivo in the Galleria mellonella infection model.  Med Microbiol Immunol. 2024 May 20;213(1):8. doi: 10.1007/s00430-024-00790-3.
Masson FM, Káradóttir S, van der Lans SPA, Doorduijn DJ, de Haas CJC, Rooijakkers SHM, Bardoel BW.: Klebsiella LPS O1-antigen prevents complement-mediated killing by inhibiting C9 polymerization.  Sci Rep. 2024 Sep 5;14(1):20701. doi: 10.1038/s41598-024-71487-z.
Scavello F, Brunetta E, Mapelli SN, Nappi E, García Martín ID, Sironi M, Leone R, Solano S, Angelotti G, Supino D, Carnevale S, Zhong H, Magrini E, Stravalaci M, Protti A, Santini A, Costantini E, Savevski V, Voza A, Bottazzi B, Bartoletti M, Cecconi M, Mantovani A, Morelli P, Tordato F, Garlanda C.: The long Pentraxin PTX3 serves as an early predictive biomarker of co-infections in COVID-19. EBioMedicine. 2024 Jul;105:105213. doi: 10.1016/j.ebiom.2024.105213. Epub 2024 Jun 21. Erratum in: EBioMedicine. 2024 Oct;108:105372. doi: 10.1016/j.ebiom.2024.105372.
Ljungquist O, Magda M, Giske CG, Tellapragada C, Nazarchuk O, Dmytriiev D, Thofte O, Öhnström V, Matuschek E, Blom AM, Riesbeck K.: Pandrug-resistant Klebsiella pneumoniae isolated from Ukrainian war victims are hypervirulent. J Infect. 2024 Dec;89(6):106312. doi: 10.1016/j.jinf.2024.106312. Epub 2024 Oct 11.
Roquigny J, Meuleman MS, El Sissy C, Martins PV, Meri S, Duval A, Lequintrec M, Fakhouri F, Chauvet S, Frémeaux-Bacchi V.: Acquired and genetic drivers of C3 and C5 convertase dysregulation in C3 glomerulopathy and immunoglobulin-associated MPGN. Nephrol Dial Transplant. 2024 Nov 13:gfae243. doi: 10.1093/ndt/gfae243. Epub ahead of print.
Bettoni S, Dziedzic M, Bierschenk D, Chrobak M, Magda M, Laabei M, King BC, Riesbeck K, Blom AM.: C4b-Binding Protein and Factor H Attenuate NLRP3 Inflammasome-Mediated Signalling Response during Group A Streptococci Infection in Human Cells. J Innate Immun. 2024;16(1):554-572. doi: 10.1159/000542434. Epub 2024 Nov 4.
Fageräng B, Cyranka L, Schjalm C, McAdam KE, Larsen CS, Heinzelbecker J, Gedde-Dahl T, Würzner R, Espevik T, Tjønnfjord GE, Garred P, Barratt-Due A, Tvedt THA, Mollnes TE. : The function of the complement system remains fully intact throughout the course of allogeneic stem cell transplantation. Front Immunol. 2024 Jun 13;15:1422370. doi: 10.3389/fimmu.2024.1422370.
Massri M, Toonen EJM, Sarg B, Kremser L, Grasse M, Fleischer V, Torres-Quesada O, Hengst L, Skjoedt MO, Bayarri-Olmos R, Rosbjerg A, Garred P, Orth-Höller D, Prohászka Z, Würzner R.: Complement C7 and clusterin form a complex in circulation.  Front Immunol. 2024 Jan 25;15:1330095. doi: 10.3389/fimmu.2024.1330095.
Avraham M, Sinkovits G, Hurler L, Prohászka Z, Fishelson Z.: Circulating mortalin in blood and activation of the alternative complement pathway as risk indicators in COVID-19 infection. ront Immunol. 2024 Apr 23;15:1337215. doi: 10.3389/fimmu.2024.1337215.
Hurler L, Mescia F, Bergamaschi L; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration; Kajdácsi E, Sinkovits G, Cervenak L, Prohászka Z, Lyons PA, Toonen EJM.: sMR and PTX3 levels associate with COVID-19 outcome and survival but not with Long COVID. iScience. 2024 Jun 1;27(7):110162. doi: 10.1016/j.isci.2024.110162.

Publications 2023:
Hurler L, Szilágyi Á, Mescia F, Bergamaschi L, Mező B, Sinkovits G, Réti M, Müller V, Iványi Z, Gál J, Gopcsa L, Reményi P, Szathmáry B, Lakatos B, Szlávik J, Bobek I, Prohászka ZZ, Förhécz Z, Csuka D, Kajdácsi E, Cervenak L, Kiszel P, Masszi T, Vályi-Nagy I, Würzner R; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration; Lyons PA, Toonen EJM, Prohászka Z.: Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups. Front Immunol. 2023 Mar 27;14:1162171. doi: 10.3389/fimmu.2023.1162171.
Larsen ML, Troldborg A, Toonen EJM, Hurler L, Prohaszka Z, Cervenak L, Hansen AG, Thiel S.: Differentiating Between Activation via the Lectin or the Classical Complement Pathway in Patients with Systemic Lupus Erythematosus. Clin Exp Immunol. 2023 Jul 5:uxad070. doi: 10.1093/cei/uxad070. Epub ahead of print.
Janet-Maitre M, Pont S, Masson FM, Sleiman S, Trouillon J, Robert-Genthon M, Gallet B, Dumestre-Perard C, Elsen S, Moriscot C, Bardoel BW, Rooijakkers SHM, Cretin F, Attrée I.: Genome-wide screen in human plasma identifies multifaceted complement evasion of Pseudomonas aeruginosa. PLoS Pathog. 2023 Jan 25;19(1):e1011023. doi: 10.1371/journal.ppat.1011023.
van der Lans SPA, Janet-Maitre M, Masson FM, Walker KA, Doorduijn DJ, Janssen AB, van Schaik W, Attrée I, Rooijakkers SHM, Bardoel BW.: Colistin resistance mutations in phoQ can sensitize Klebsiella pneumoniae to IgM-mediated complement killing. Sci Rep. 2023 Aug 3;13(1):12618. doi: 10.1038/s41598-023-39613-5.
Kellnerová S, Huber S, Massri M, Fleischer V, Losso K, Sarg B, Kremser L, Talasz H, He X, Varrone E, Brigotti M, Ardissino G, Orth-Höller D, Würzner R.: Enzymatic Cleavage of Stx2a in the Gut and Identification of Pancreatic Elastase and Trypsin as Possible Main Cleavers. Microorganisms. 2023 Oct 4;11(10):2487. doi: 10.3390/microorganisms11102487. PMID: 37894145; PMCID: PMC10609011.
Cyranka L, Mariegaard I, Skjødt MO, Bayarri-Olmos R, Mollnes TE, Garred P, Rosbjerg A.: Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody. J Innate Immun. 2023;15(1):836-849. doi: 10.1159/000535084. Epub 2023 Nov 10.
Ma YJ, Parente R, Zhong H, Sun Y, Garlanda C, Doni A.: Complement-pentraxins synergy: Navigating the immune battlefield and beyond.  Biomed Pharmacother. 2023 Dec 31;169:115878. doi: 10.1016/j.biopha.2023.115878. Epub 2023 Nov 11.
González-Del-Barrio L, Pérez-Alós L, Cyranka L, Rosbjerg A, Nagy S, Prohászka Z, Garred P, Bayarri-Olmos R.: MAP-2:CD55 chimeric construct effectively modulates complement activation. FASEB J. 2023 Nov;37(11):e23256. doi: 10.1096/fj.202300571R.
Götz MP, Skjoedt MO, Bayarri-Olmos R, Hansen CB, Pérez-Alós L, Jarlhelt I, Benfield T, Rosbjerg A, Garred P.: Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19. J Innate Immun. 2023;15(1):122-135. doi: 10.1159/000525508. Epub 2022 Jul 11.

Publications 2022:
Medeiros PMC, Schjalm C, Christiansen D, Sokolova M, Pischke SE, Würzner R, Mollnes TE, Barratt-Due A.: Vitamin C, Hydrocortisone, and the Combination Thereof Significantly Inhibited Two of Nine Inflammatory Markers Induced by Escherichia Coli But Not by Staphylococcus Aureus - When Incubated in Human Whole Blood. Shock. 2022 Jan 1;57(1):72-80. doi: 10.1097/SHK.0000000000001834.
Magda M, Bettoni S, Laabei M, Fairley D, Russo TA, Riesbeck K, Blom AM.: Clinical Isolates of Acinetobacter spp. Are Highly Serum Resistant Despite Efficient Recognition by the Complement System. Front Immunol. 2022 Jan 31;13:814193. doi: 10.3389/fimmu.2022.814193.
Sinkovits G, Réti M, Müller V, Iványi Z, Gál J, Gopcsa L, Reményi P, Szathmáry B, Lakatos B, Szlávik J, Bobek I, Prohászka ZZ, Förhécz Z, Mező B, Csuka D, Hurler L, Kajdácsi E, Cervenak L, Kiszel P, Masszi T, Vályi-Nagy I, Prohászka Z.: Associations between the von Willebrand Factor-ADAMTS13 Axis, Complement Activation, and COVID-19 Severity and Mortality. Thromb Haemost. 2022 Feb;122(2):240-256. doi: 10.1055/s-0041-1740182. Epub 2022 Jan 21.
Henry BM, Sinkovits G, Szergyuk I, de Oliveira MHS, Lippi G, Benoit JL, Favaloro EJ, Pode-Shakked N, Benoit SW, Cooper DS, Müller V, Iványi Z, Gál J, Réti M, Gopcsa L, Reményi P, Szathmáry B, Lakatos B, Szlávik J, Bobek I, Prohászka ZZ, Förhécz Z, Csuka D, Hurler L, Kajdácsi E, Cervenak L, Mező B, Kiszel P, Masszi T, Vályi-Nagy I, Prohászka Z.: Complement Levels at Admission Reflecting Progression to Severe Acute Kidney Injury (AKI) in Coronavirus Disease 2019 (COVID-19): A Multicenter Prospective Cohort Study. Front Med (Lausanne). 2022 Apr 29;9:796109. doi: 10.3389/fmed.2022.796109.
Bertacchi G, Posch W, Wilflingseder D.: HIV-1 Trans Infection via TNTs Is Impeded by Targeting C5aR. Biomolecules. 2022 Feb 15;12(2):313. doi: 10.3390/biom12020313.
Massri M, Foco L, Würzner R.: Comprehensive Update and Revision of Nomenclature on Complement C6 and C7 Variants. J Immunol. 2022 Jun 15;208(12):2597-2612. doi: 10.4049/jimmunol.2200045.
Khattab A, Rezola M, Barroso M, Kyrklund M, Pihlajamaa T, Freitag TL, van Gemert GJ, Bousema T, Permi P, Turunen O, Sauerwein R, Luty AJF, Meri S.: Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the Plasmodium falciparum parasite. Front Immunol. 2022 Nov 21;13:1051161. doi: 10.3389/fimmu.2022.1051161.
de Boer E, Sokolova M, Quach HQ, McAdam KE, Götz MP, Chaban V, Vaage J, Fageräng B, Woodruff TM, Garred P, Nilsson PH, Mollnes TE, Pischke SE.: Synthetic Oligodeoxynucleotide CpG Motifs Activate Human Complement through Their Backbone Structure and Induce Complement-Dependent Cytokine Release. J Immunol. 2022 Nov 1;209(9):1760-1767. doi: 10.4049/jimmunol.2101191. Epub 2022 Sep 14.
Sinkovits G, Schnur J, Hurler L, Kiszel P, Prohászka ZZ, Sík P, Kajdácsi E, Cervenak L, Maráczi V, Dávid M, Zsigmond B, Rimanóczy É, Bereczki C, Willems L, Toonen EJM, Prohászka Z.: Evidence, detailed characterization and clinical context of complement activation in acute multisystem inflammatory syndrome in children. Sci Rep. 2022 Nov 17;12(1):19759. doi: 10.1038/s41598-022-23806-5.
Hurler L, Toonen EJM, Kajdácsi E, van Bree B, Brandwijk RJMGE, de Bruin W, Lyons PA, Bergamaschi L; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration; Sinkovits G, Cervenak L, Würzner R, Prohászka Z: Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs Front Immunol. 2022 Nov 4;13:1039765. doi: 10.3389/fimmu.2022.1039765.

Publications 2021:
Sinkovits G, Mező B, Réti M, Müller V, Iványi Z, Gál J, Gopcsa L, Reményi P, Szathmáry B, Lakatos B, Szlávik J, Bobek I, Prohászka ZZ, Förhécz Z, Csuka D, Hurler L, Kajdácsi E, Cervenak L, Kiszel P, Masszi T, Vályi-Nagy I, Prohászka Z.: Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection. Front Immunol. 2021 Mar 25;12:663187. doi: 10.3389/fimmu.2021.663187.
Posch W, Vosper J, Noureen A, Zaderer V, Witting C, Bertacchi G, Gstir R, Filipek PA, Bonn GK, Huber LA, Bellmann-Weiler R, Lass-Flörl C, Wilflingseder D.: C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2-infected primary human airway epithelia. J Allergy Clin Immunol. 2021 Jun;147(6):2083-2097.e6. doi: 10.1016/j.jaci.2021.03.038. Epub 2021 Apr 20.
Huber S, Massri M, Grasse M, Fleischer V, Kellnerová S, Harpf V, Knabl L, Knabl L Sr, Heiner T, Kummann M, Neurauter M, Rambach G, Speth C, Würzner R.: Systemic Inflammation and Complement Activation Parameters Predict Clinical Outcome of Severe SARS-CoV-2 Infections. Viruses. 2021 Nov 26;13(12):2376. doi: 10.3390/v13122376.


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PROGRAMME SPEAKER

Reinhard Würzner, M.D., Ph.D.
Schöpfstraße 41
A-6020 Innsbruck

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This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 860044