Main research topics in the Research Lab are related to the complement system. Complement linked rare diseases in the focus of our research are hereditary angioedema, immunodeficiencies (infections and autoimmunity related to complement deficiency), thrombotic microangiopathies, and glomerulonephritis. The primary motivation is to organize and conduct clinical research projects to describe risk factors and pathogenic mechanisms in these diseases. In addition, we have multiple projects on diseases or states, where complement is one mediator in the complex disease pathogenesis. Large patient material-based sample collections, linked with clinical data, are available for such observational projects. In addition, we aim to develop or establish novel assays (genetic determinations and immunoassays) to facilitate the improved diagnosis of these diseases. Having the diagnostic and research Lab in the same facility, we are in the unique position to be able to work on unresolved clinical questions, for example molecular characterization of novel mutations in patients with complement linked diseases. This 'molecular hunting' makes research in our Lab really fascinating and reasonable.

Réti M, Farkas P, Csuka D, Rázsó K, Schlammadinger Á, Udvardy ML, Madách K, Domján G, Bereczki C, Reusz GS, Szabó AJ, Prohászka Z. Complement activation in thrombotic thrombocytopenic purpura. J Thromb Haemost 10(5):791-8 (2012).

Megyeri M, Makó V, Beinrohr L, Doleschall Z, Prohászka Z, Cervenak L, Závodszky P, Gál P. Complement protease MASP-1 activates human endothelial cells: PAR4 activation is a link between complement and endothelial function. J Immunol 183(5):3409-16 (2009).

Molvarec A, Rigó J Jr, Bõze T, Derzsy Z, Cervenak L, Makó V, Gombos T, Udvardy ML, Hársfalvi J, Prohászka Z. Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia. Thromb Haemost 101(2):305-11 (2009).

Szilágyi A, Kiss N, Bereczki C, Tálosi G, Rácz K, Túri S, Györke Z, Simon E, Horváth E, Kelen K, Reusz GS, Szabó AJ, Tulassay T, Prohászka Z. The role of complement in Streptococcus pneumoniae-associated haemolytic uraemic syndrome. Nephrol Dial Transplant 28(9):2237-45 (2013).

Csuka D, Veszeli N, Imreh É, Zotter Z, Skopál J, Prohászka Z, Varga L, Farkas H. Comprehensive study into the activation of the plasma enzyme systems during attacks of hereditary angioedema due to C1-inhibitor deficiency. Orphanet J Rare Dis 10:132 (2015).